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The extent to which this interaction is an important clinical problem depends on the extent of the inhibition of P450 2D6 by the antidepressant and the therapeutic index of the co-administered drug?

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Metabolismo: A sildenafila sofre depuração hepática principalmente pelas isoenzimas microssomais CYP3A4 (via principal) e CYP2C9 (via secundária)? Dziś mamy ich na rynku niesamowicie duże zatrzęsienie?

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